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> 【CD39】
CD39信息
英文名称：Ectonucleoside triphosphate diphosphohydrolase 1
中文名称：外核苷三磷酸二磷酸水解酶-1
靶点别称：CD39 Antigen，CD39，EC 3.6.1.5，NTPDase-1，NTPDase 1，ATPDase，SPG64，EC:3.6.1.5，Ecto-ATPase 1，Lymphoid cell activation antigen，ENTPD1，Ectonucleoside Triphosphate Diphosphohydrolase 1，Ecto-ATPDase 1，Ecto-Apyrase，Ecto-ATP diphosphohydrolase 1，EC 3.6.1
中文名称：外核苷三磷酸二磷酸水解酶-1
靶点别称：CD39 Antigen，CD39，EC 3.6.1.5，NTPDase-1，NTPDase 1，ATPDase，SPG64，EC:3.6.1.5，Ecto-ATPase 1，Lymphoid cell activation antigen，ENTPD1，Ectonucleoside Triphosphate Diphosphohydrolase 1，Ecto-ATPDase 1，Ecto-Apyrase，Ecto-ATP diphosphohydrolase 1，EC 3.6.1
上市药物数量：0
临床药物数量：5
最高研发阶段：临床二期
临床药物数量：5
最高研发阶段：临床二期
CD39产品列表
产品库
属性
评论(3)
CD9-H52H4|Human CD39 / ENTPD1 Protein, His Tag (active enzyme)
- 136XXXXXXX6
- 购买蛋白用于测试CD39封闭性抗体封闭CD39水解ATP的功能实验。通过系列梯度CD39抗体与一定浓度的CD39（0.5ug/ml）孵育，再加入50uM ATP,用CTG检测，得到很好的曲线。证明该蛋白具有很好的ATP酶水解功能。
- 2019-11-11
14人赞
CD9-H52H4|Human CD39 / ENTPD1 Protein, His Tag (active enzyme)
- 180XXXXXXX9
- 购买CD39用于动物免疫、后续抗体筛选和检测。抗原蛋白通过检测，纯度、活性方面都非常好，目前已准备免疫，期待获得良好的免疫效果。
- 2021-12-09
2人赞
CD9-C52H3|Cynomolgus CD39 / ENTPD1 Protein, His Tag (MALS verified) (active enzyme)
- 180XXXXXXX9
- Cynomolgus CD39用于免疫血清效价检测及后续抗体筛选，前期检测血清效价结果较为理想，期待后续的抗体筛选取得好结果
- 2022-01-10
1人赞
CD39 分子别名
CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1
CD39 分子背景
CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
CD39 前沿进展
CD39临床药物信息
| 英文名称 | 研发代码 | 研发阶段 | 公司 | 适应症 | 临床试验 |
|---|---|---|---|---|---|
| IPH-5201 | IPH-5201 | 临床一期 | Inserm, Orega Biotech | 实体瘤 | 详情 |
| JS-019 | JS-019 | 临床一期 | 北京恩瑞尼生物科技股份有限公司 | 肿瘤 | 详情 |
| SRF-617 | SRF-617 | 临床二期 | Surface Oncology | 实体瘤, 前列腺癌 | 详情 |
| TTX-030 | TTX-030 | 临床一期 | Tizona Therapeutics, 艾伯维 | 实体瘤, 淋巴瘤 | 详情 |
| ES-002 | ES-002 | 临床一期 | 科望（上海）生物医药科技有限公司 | 实体瘤, 肿瘤 | 详情 |
| ES-002023(Elpiscience Biopharma) | 临床一期 | 科望（上海）生物医药科技有限公司 | 实体瘤 | 详情 | |
| PUR-001 | PUR-001 | 临床一期 | Purinomia Biotech Inc | 实体瘤 | 详情 |
