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Integrin alpha V beta 5信息

英文名称:Integrin alpha-V/beta-5
中文名称:整合素α-2/β-5复合体
靶点别称:Receptors, Vitronectin
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Integrin alpha V beta 5 分子别名

Integrin alpha V beta 5,ITGAVB5,ITGAV&ITGB5,ITGAV&B5

Integrin alpha V beta 5 分子背景

Integrin alpha V beta 5 (ITGAV & ITGB5 or ITGAVB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAVB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAVB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Integrin alpha V beta 5 参考文献

Integrin alpha V beta 5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Risuteganib ALG-1001 临床二期 Allegro Ophthalmics 视网膜病变, 糖尿病黄斑水肿, 糖尿病视网膜病变, 年龄相关性黄斑变性 详情

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