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Integrin alpha V beta 5信息

英文名称:Integrin alpha-V/beta-5
中文名称:整合素α-2/β-5复合体
靶点别称:Receptors, Vitronectin
上市药物数量:0
临床药物数量:1
最高研发阶段:临床前

Integrin alpha V beta 5 分子别名

Integrin alpha V beta 5,ITGAV&ITGB5

Integrin alpha V beta 5 分子背景

Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Integrin alpha V beta 5 前沿进展

Integrin alpha V beta 5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Cilengitide EMD-85189; EMD-121974; NSC-707544 默克雪兰诺 详情

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