Recombinant Proteins iso9001 ISO13485
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VCAM-1信息

英文名称:Vascular cell adhesion molecule 1
中文名称:血管细胞粘附分子1
靶点别称:VCAM1,Vascular cell adhesion protein 1,V-CAM 1,CD106,Vascular Cell Adhesion Molecule 1,CD106 Antigen,INCAM-100,VCAM-1,Vascular Cell Adhesion Molecule-1
上市药物数量:1
临床药物数量:1
最高研发阶段:批准上市

VCAM-1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
VC1-H5224
Human
Human VCAM-1 / CD106 Protein, His Tag
VC1-H5253
Human
Human VCAM-1 / CD106 Protein, Fc Tag
 
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VCAM-1 分子别名

VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1

VCAM-1 分子背景

Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.

VCAM-1 参考文献

VCAM-1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Tocopherol acetate 生育酚醋酸酯 DSE-9912 批准上市 Ephynal, Aquasol E 静脉血栓栓塞, 动脉粥样硬化, 间歇性跛行, 血栓形成, 糖尿病视网膜病变 详情

VCAM-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
99mTccAbVCAM1‐5 99mTccAbVCAM1‐5 临床一期 Medico-Economic Evaluation Unit , University Hospital, Grenoble 动脉粥样硬化 详情

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