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DLL4信息

英文名称:Delta-like protein 4
中文名称:δ样蛋白-4
靶点别称:Delta-Like Protein 4,Notch Ligand Delta-2,DLL4,Delta4,Delta-Like 4 (Drosophila),Delta-Like 4 Homolog (Drosophila),AOS6,Hdelta2,Notch Ligand DLL4,Delta Like Canonical Notch Ligand 4,Delta 4,Delta Ligand 4,Delta-Like 4 Protein,Drosophila Delta Homolog 4,Delta-Like 4 Homolog
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

DLL4 分子别名

DLL4,Delta4

DLL4 分子背景

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.

DLL4 前沿进展

DLL4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dilpacimab ABT-165; DVD-Ig ABT-165 临床一期 艾伯维 实体瘤, 肿瘤 详情
Navicixizumab OMP-305B83 临床三期 Oncomed Pharmaceuticals Inc 卵巢癌, 实体瘤, 胃癌, 三阴性乳腺肿瘤, 结直肠癌, 腹膜癌, 输卵管癌 详情
TR-009 NOV-1501; ABL001-ABL Bio; ABL-001-ABL Bio; ES-104; CTX-009 临床二期 Abl Bio 实体瘤, 胆道癌, 结直肠癌 详情

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