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 >  Protein>GAS6 >GA6-H5247

Human GAS6 (471-678) Protein, His Tag (MALS verified)

分子别名(Synonym)

GAS6,GAS-6,AXLLG

表达区间及表达系统(Source)

Human GAS6 (471-678) Protein, His Tag (GA6-H5247) is expressed from human 293 cells (HEK293). It contains AA Phe 471 - Ala 678 (Accession # Q14393-2).

Predicted N-terminus: His

Request for sequence

蛋白结构(Molecular Characterization)

GAS6 Structure

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 24.5 kDa. The protein migrates as 26-27 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

GAS6 SDS-PAGE

Human GAS6 (471-678) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS

GAS6 SEC-MALS

The purity of Human GAS6 (471-678) Protein, His Tag (Cat. No. GA6-H5247) is more than 90% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

Report

 

背景(Background)

GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

 

前沿进展

 
 
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GAS6靶点信息
英文全称:Growth arrest-specific protein 6
中文全称:生长停滞特异性蛋白6
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床三期
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