分子别名(Synonym)
IL1RAP,IL-1RAcP,C3orf13,IL1R3
表达区间及表达系统(Source)
PE-Labeled Human IL-1 RAcP / IL-1 R3, His Tag (ILP-HP2H3) is produced via site-specific conjugation of PE to Human IL-1 RAcP / IL-1 R3 Protein, His Tag under optimal conditions with a proprietary technology. PE-Labeled Human IL-1 RAcP, His Tag (ILP-HP2H3) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Glu 359 (Accession # Q9NPH3-1).
Predicted N-terminus: Ser 21
Request for sequence
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus
The protein has a calculated MW of 42.7 kDa.
偶联(Conjugate)
PE
Excitation Wavelength: 488 nm / 561 nm
Emission Wavelength: 575 nm
应用说明(Application)
Please note that this product is NOT compatible to streptavidin detection system.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.5%BSA, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
Interleukin-1 receptor accessory protein (IL1RAP or IL-1RAcP) is also known as Interleukin-1 receptor 3 (IL-1R-3 or IL-1R3), C3orf13, which belongs to the interleukin-1 receptor family. IL1RAP contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RAP is detected in liver, skin, placenta, thymus and lung. IL-1R3 / IL1RAP is coreceptor with IL1R1, associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.