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 > 【Siglec-10】重组蛋白信息

Siglec-10信息

英文名称:Sialic acid-binding Ig-like lectin 10
中文名称:唾液酸结合免疫球蛋白样凝集素-10
靶点别称:Siglec-like protein 2,SLG2,Siglec-10,SIGLEC10
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Siglec-10 Molecule Synonym Name

SIGLEC10,MGC126774,PRO940,Siglec10,SLG2

Siglec-10 分子背景

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Siglec-10 参考文献

Siglec-10临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CD24-Fc CD24-Fc; CD24-Fc-IgG; HAS-CD24 临床三期 OncoImmune, National Institute of Neurological Disorders and Stroke, 密歇根大学, The Ohio State University Comprehensive Cancer Center 移植物抗宿主病, 新型冠状病毒肺炎 详情

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