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Cathepsin B信息

英文名称:Cathepsin B
中文名称:组织蛋白酶B
靶点别称:Cathepsin B1,CPSB,Cathepsin B,APP secretase,CTSB,APPS,Cathepsin B heavy chain,Cathepsin B light chain
上市药物数量:0
临床药物数量:8
最高研发阶段:临床三期

Cathepsin B产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CTB-H5222
Human
Human Cathepsin B / CTSB / APPS Protein

Cathepsin B 分子别名

CTSB,CPSB,APPS

Cathepsin B 分子背景

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B 参考文献

Cathepsin B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BI-1181181 BI-1181181; VTP-37948 临床一期 Vitae, 勃林格殷格翰 阿尔茨海默病 详情
VBY-376 VBY-376,VBY376 临床一期 ViroBay 肝纤维化, 非酒精性脂肪性肝炎 详情
Aoxistatin AB-007; E-64-d 临床三期 大正, 大日本住友 肌肉营养不良症
Begacestat Begacestat; GSI-953; WAY-210953 临床一期 辉瑞 阿尔茨海默病 详情
AL-101 BMS-906024,BMS906024,AL-101; BMS-906024 临床二期 百时美施贵宝, Ayala Pharmaceuticals 腺样囊性癌, T细胞淋巴母细胞淋巴瘤, 实体瘤, 急性淋巴细胞白血病 详情
BMS-986115 BMS-986115,BMS986115 临床一期 百时美施贵宝 实体瘤 详情
MK-0752 MK-0752; L-000891675,MK0752,L000891675 临床一期 默沙东, 美国国立癌症研究所 乳腺癌, 实体瘤, 胰腺癌 详情
EVP-0962 EVP-0962; EVP-0015962 临床二期 FORUM pharmaceuticals 阿尔茨海默病 详情

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