Cathepsin B 分子别名
Cathepsin B 分子背景
Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.
Cathepsin B 参考文献
- Basrur V., et al., 2003, J. Proteome Res. 2:69-79.
- Chi A., et al., 2006, J. Proteome Res. 5:3135-3144.
- Royer-Zemmour B., et al., 2008, Hum. Mol. Genet. 17:3617-3630.
- Cao L., et al., 1994, Gene 139 (2): 163–9.