Siglec-15 靶点蛋白|抗体药物|临床药物信息

Siglec-15信息

英文名称：Sialic acid-binding Ig-like lectin 15
中文名称：唾液酸结合免疫球蛋白样凝集素-15
靶点别称：SIGLEC15，Sialic Acid Binding Ig Like Lectin 15，CD33 Antigen-Like 3，CD33L3，Sialic Acid-Binding Ig-Like Lectin 15，SIGLEC-15，HsT1361，CD33 Molecule-Like 3，Sialic Acid Binding Ig-Like Lectin 15

上市药物数量：0
临床药物数量：2
最高研发阶段：临床二期

Siglec-15产品列表

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产品库

在线 (8)

物种

标签

属性

Protein (8)

标记

货号	物种	产品描述
SG5-H52H3	Human	Human Siglec-15 / CD33L3 Protein, His Tag
SG5-C52H6	Cynomolgus	Cynomolgus Siglec-15 / CD33L3 Protein, His Tag
SG5-M52H7	Mouse	Mouse Siglec-15 / CD33L3 Protein, His Tag
SG5-H82E9	Human	Biotinylated Human Siglec-15 / CD33L3 Protein, His,Avitag (recommended for biopanning)
SG5-C5253	Cynomolgus	Cynomolgus Siglec-15 / CD33L3 Protein, Fc Tag
SG5-H5253	Human	Human Siglec-15 / CD33L3 Protein, Fc Tag
SG5-H82F5	Human	Biotinylated Human Siglec-15 / CD33L3 Protein, Fc,Avitag
SG5-H5254	Human	Human Siglec-15 / CD33L3 Protein, Mouse IgG2a Fc Tag (MALS verified)

SG5-C52H6|Cynomolgus Siglec-15 / CD33L3 Protein, His Tag

182XXXXXXX2

2人赞

三个种属的Siglec15都使用过分别用来测定同一个抗体的亲和力，猴子的亲和力与人的相当，大约为7E-10
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2020-01-10

SG5-M52H7|Mouse Siglec-15 / CD33L3 Protein, His Tag

182XXXXXXX2

5人赞

Mouse SIglec15与抗癌新药做亲和力测定，有一定的解离趋势，但是亲和力还有2E-9.
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2020-01-10

SG5-H52H3|Human Siglec-15 / CD33L3 Protein, His Tag

182XXXXXXX2

4人赞

到货速度很快的产品，使用一款临床期的抗体与Human Siglec15做BLI实验，结果显而易见，具有很高的亲和力，解离速度很慢。
>
2020-01-10

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Siglec-15 Molecule Synonym Name

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

Siglec-15 分子背景

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Siglec-15 参考文献

Siglec-15临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
NC-318	5G-12; NC-318	临床二期	耶鲁大学医学院	卵巢癌, 头颈部鳞状细胞癌, 三阴性乳腺肿瘤, 非小细胞肺癌	详情
DS-1501	DS-1501	临床一期	第一三共株式会社	骨质疏松症

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Siglec-15 重组蛋白