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EphB4信息

英文名称:Ephrin type-B receptor 4
中文名称:B型肝配蛋白受体-4
靶点别称:Ephrin type-B receptor 4,MYK1,EPHB4,HTK,EPH Receptor B4,Tyrosine-Protein Kinase TYRO11,TYRO11,Tyrosine-Protein Kinase Receptor HTK,Soluble EPHB4 Variant 2,Soluble EPHB4 Variant 3,Ephrin Receptor EphB4,EC 2.7.10.1,HFASD,LMPHM7,CMAVM2,EC 2.7.10,EC:2.7.10.1,Soluble EPHB4 Variant 1,Receptor, EphB4,Hepatoma transmembrane kinase
上市药物数量:0
临床药物数量:1
最高研发阶段:无进展

EphB4产品列表

 
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EphB4 分子别名

EphB4,HTK,MYK1,TYRO11

EphB4 分子背景

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

EphB4 前沿进展

EphB4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
JI-101 JI-101; CGI-1842 Gilead Sciences Inc, Jubilant Innovation 详情
sEphB4-HSA Vas-01; sEphB4-HSA Vasgene 详情
TG-100801 TG-100801 赛诺菲 详情

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