Recombinant Proteins iso9001 ISO13485
搜索
 > 【EphB4】重组蛋白信息

EphB4信息

英文名称:Ephrin type-B receptor 4
中文名称:B型肝配蛋白受体-4
靶点别称:LMPHM7,HTK,EPH Receptor B4,Tyrosine-Protein Kinase TYRO11,TYRO11,Tyrosine-Protein Kinase Receptor HTK,Soluble EPHB4 Variant 2,Soluble EPHB4 Variant 3,Ephrin Receptor EphB4,EC 2.7.10.1,HFASD,Ephrin type-B receptor 4,MYK1,EPHB4,CMAVM2,EC 2.7.10,Hepatoma tra
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

EphB4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
EP4-H8229
Human
Biotinylated Human EphB4 Protein, His Tag, ultra sensitivity (primary amine labeling)
EP4-H5229
Human
Human EphB4 Protein, His Tag
 
评论(0)
 

EphB4 分子别名

EphB4,HTK,MYK1,TYRO11

EphB4 分子背景

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

EphB4 参考文献

EphB4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
sEphB4-HSA Vas-01; sEphB4-HSA 临床二期 Vasgene 卡波济氏肉瘤 详情

消息提示

请输入您的联系方式,再点击提交!

确定