CD3 epsilon 靶点蛋白|抗体药物|临床药物信息

CD3 epsilon信息

英文名称：T-cell surface glycoprotein CD3 epsilon chain
中文名称：T细胞表面糖蛋白CD3ε链
靶点别称：T-cell surface antigen T3/Leu-4 epsilon chain，CD3-Epsilon

上市药物数量：0
临床药物数量：10
最高研发阶段：申请上市

CD3 epsilon产品列表

筛选结果

产品库

在线 (12)

物种

标签

属性

标记

货号	物种	产品描述
CDE-H5223	Human	Human CD3 epsilon Protein, His Tag (MALS verified)
CDE-H5256	Human	Human CD3 epsilon Protein, Fc,His Tag
CDE-C5226	Cynomolgus	Cynomolgus CD3 epsilon Protein, His Tag (MALS verified)
CDE-C5254	Cynomolgus	Cynomolgus CD3 epsilon Protein, Fc,His Tag
CDE-M5256	Mouse	Mouse CD3 epsilon Protein, Fc Tag
CDE-H82E1	Human	Biotinylated Human CD3 epsilon Protein, His,Avitag™
CDN-H5253	Human	Human CD3 epsilon Protein, Mouse IgG2a Fc Tag (MALS verified)
MBS-K026	Human	Human CD3E-coupled Magnetic Beads
CDE-HR2H4	Human	HRP-Human CD3 epsilon Protein, His Tag
CDE-M525a	Mouse	Biotinylated Anti-Human CD3 Antibody, Mouse IgG2a,Avitag™ (Clone: OKT3), premium grade
CDE-H8224	Human	Biotinylated Human CD3 epsilon Protein, His Tag, ultra sensitivity (primary amine labeling)
CDE-C52H3	Canine	Canine CD3 epsilon Protein, His Tag (MALS verified)

CDE-H5223|Human CD3 epsilon Protein, His Tag (MALS verified)

152XXXXXXX4

5人赞

这款CD3e 大概是我用的最多和最久的一个抗原，此抗原已经“服务”过多个项目，之所以会回购，最多的原因还是因为抗原的稳定性好，批次间的一致性好，方法重现性好。
2020-04-07

CDE-H5256|Human CD3 epsilon Protein, Fc,His Tag

132XXXXXXX8

4人赞

紧跟双抗研发步伐，Anti-CD3 scFv-his形式的单抗筛选用该蛋白做ELISA和SPR均有良好的结果，用于scFv串联的无Fc的双抗也一样好用。
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2021-12-25

CDE-C5226|Cynomolgus CD3 epsilon Protein, His Tag (MALS verified)

132XXXXXXX8

3人赞

单独的his tag标签的蛋白主要用于杂交瘤上清阶段的筛选和鼠源抗体的鉴定，背景干净，活性稳定。
>
2021-12-25

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CD3 epsilon 分子别名

FLJ18683,T3E,TCRE,CD3E,CD3-epsilon

CD3 epsilon 分子背景

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

CD3 epsilon 前沿进展

CD3 epsilon临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Glofitamab	RO-7082859; RG-6026	临床三期	罗氏	B-细胞淋巴瘤, 弥漫性大B-细胞淋巴瘤, 滤泡中心淋巴瘤, 非霍奇金淋巴瘤, 淋巴瘤	详情
Gresonitamab	AMG-910	临床一期	安进	胃癌, 食道癌, 腺癌	详情
Tarlatamab	AMG-757	临床二期	安进	小细胞肺癌, 前列腺癌	详情
Elranatamab	PF-06863135	临床三期	辉瑞制药有限公司	骨髓瘤, 多发性骨髓瘤	详情
Obrindatamab	MGD-009; B7-H3 x CD3	临床二期	Macrogenics Inc	滑膜肉瘤, 黑色素瘤, 非小细胞肺癌, 甲状腺瘤, 神经母细胞瘤, 神经纤维肉瘤, 肉瘤, 前列腺癌, 乳腺癌, 卵巢癌, 膀胱癌, 间皮组织肿瘤, 肾母细胞瘤, 胰腺癌, 结肠癌, 肾细胞癌, 头颈部鳞状细胞癌, 横纹肌肉瘤	详情
Emerfetamab	AMG-673; AMG673	临床一期	安进	急性髓细胞样白血病	详情
Eluvixtamab	MT-114; AMG-330	临床一期	安进	骨髓增生异常综合征, 急性髓细胞样白血病	详情
Etevritamab	AMG-596	临床一期	安进	胶质母细胞瘤	详情
Pacanalotamab	AMG-420; BI-836909	临床一期	Micromet Inc	多发性骨髓瘤	详情

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CD3 epsilon