B7-H5 靶点蛋白|抗体药物|临床药物信息

B7-H5信息

英文名称：V-domain Ig suppressor of T-cell activation
中文名称：T细胞活化的免疫球蛋白抑制V型结构域
靶点别称：Dies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha

上市药物数量：0
临床药物数量：4
最高研发阶段：临床一期

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在线 (7)

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Protein (7)

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货号	物种	产品描述
B75-H52H0	Human	Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)
B75-H82F3	Human	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Fc,Avitag™
B75-M52H7	Mouse	Mouse B7-H5 / Gi24 / VISTA Protein, His Tag
B75-C5220	Rhesus macaque	Rhesus macaque B7-H5 / Gi24 / VISTA Protein, His Tag
B75-H5258	Human	Human B7-H5 / Gi24 / VISTA Protein, Mouse IgG2a Fc Tag, low endotoxin
B75-H5259	Human	Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
B75-H82E1	Human	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Avitag,His Tag

B75-H52H0|Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)

131XXXXXXX6

1人赞

我一般是不会主动给试剂做评价的，一是觉得没有什么意义二是觉得害怕自己不严谨的试验会对别人造成困扰。然后这试剂我是经过过了多次的试验之后才敢说的，值得购买，值得试用，相信我你会得到满意的结果！
2022-04-21

B75-H52H0|Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)

138XXXXXXX4

0人赞

这个公司是我最近一直合作的品牌，他家的试剂不仅发货快，而且售后也好，我们试验过程中遇见的所有问题都可以得到耐心的解答，完全没有任何忧虑，值得推荐！希望所有的科研工作者都能发现这个宝藏品牌！
2022-04-21

B75-H52H0|Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)

151XXXXXXX5

0人赞

通过Elisa的鉴别我们发现该特异性效果非常好，同时也对我同家族的对比实验起到了关键的说明作用，同时我也发现针对别的厂家有很强的优势，比义翘的对比有很强的竞争优势。
2022-04-21

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B7-H5分子别名

B7-H5,SISP1,Gi24,VISTA

B7-H5分子背景

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

B7-H5临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
W-0180	W-0180	临床一期	法国皮尔法伯制药公司上海代表处	实体瘤	详情
Onvatilimab	CI-8993; JNJ-61610588	临床一期	杨森, Immunext Inc	实体瘤, 肿瘤	详情
HMBD-002	HMBD-002	临床一期	蜂鸟生物科技	实体瘤, 三阴性乳腺癌, 肿瘤, 非小细胞肺癌, 转移癌	详情

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