Integrin alpha 2b beta 3 靶点蛋白|抗体药物|临床药物信息

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货号	物种	产品描述	蛋白结构	纯度	活性
IT3-H52W8	Human	Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free

IT3-H52W8|Human Integrin alpha 2b beta 3 (ITGAIIb&ITGB3) Heterodimer Protein, His Tag&Tag Free

135XXXXXXX2

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使用该蛋白作为elisa铺板抗原，检测不同标记的目标抗体对整合素的结合情况，阴性对照背景低，结果可重复，效果非常不错
2021-12-16

Integrin alpha 2b beta 3 分子别名

Integrin alpha 2b beta 3,ITGAIIb&ITGB3

Integrin alpha 2b beta 3 分子背景

Integrin alpha IIb beta 3 exist in a conformational equilibrium clustered around four main states. These conformations range from a compact bent nodule to two partially extended intermediate conformers and finally to a fully upright state. Activation of blood platelets by physiological stimuli at sites of vascular injury induces inside-out signaling, resulting in a conformational change of the prototype Integrin alpha IIb beta 3 from an inactive to an active state competent to bind soluble fibrinogen. Furthermore, ligand occupancy of Integrin alpha IIb beta 3 outside-in signaling and additional conformational changes of the receptor, leading to the exposure of extracellular neoepitopes termed ligand-induced binding sites (LIBS), which are recognized by anti-LIBS monoclonal antibodies.

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Integrin alpha 2b beta 3

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