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VEGF-D信息

英文名称:Vascular endothelial growth factor D
中文名称:血管内皮生长因子D
靶点别称:C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D),FIGF,c-Fos-induced growth factor,VEGFD,VEGF-D,Vascular Endothelial Growth Factor D
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

VEGF-D产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
VED-H5228
Human
Human VEGF-D Protein, His Tag
 
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VEGF-D 分子别名

FIGF,VEGFD

VEGF-D 分子背景

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.

VEGF-D 参考文献

VEGF-D临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
EG-016 EG-016; Ad-VEGF-A 临床二期 Ark Therapeutics 外周血管疾病
EG-011 EG-011; Ad-VEGF-D 临床二期 Ark Therapeutics 心绞痛
OPT-302 OPT-302; VGX-300 临床三期 Orphan Europe Sarl 病理性新生血管, 视网膜病变, 糖尿病黄斑水肿, 视网膜变性, 年龄相关性黄斑变性 详情

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