TRAIL R1 靶点蛋白|抗体药物|临床药物信息

TRAIL R1信息

英文名称：Tumor necrosis factor receptor superfamily member 10A
中文名称：肿瘤坏死因子受体超家族成员10A
靶点别称：TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2

上市药物数量：0
临床药物数量：5
最高研发阶段：申请上市

TRAIL R1产品列表

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产品库

在线 (2)

物种

Human (2)

标签

属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
TR1-H5228	Human	Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag
TR1-H5254	Human	Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

TR1-H5254|Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

182XXXXXXX2

4人赞

购买TNFRSF10A的目的是用来测定Binding的，首先测定了一下纯度，从附件中SEC的结果也可以看出纯度还不错，有94.8%
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2019-09-30

TRAIL R1 分子别名

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

TRAIL R1 分子背景

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

TRAIL R1 前沿进展

TRAIL R1临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Rilunermin alfa	SCB-313 (TRAIL-Trimer)	临床一期	四川三叶草生物制药有限公司	胸水, 腹水, 腹膜癌, 恶性胸腔积液	详情
HLX56	HLX56; HLX-56	临床一期	上海复宏汉霖生物技术股份有限公司	实体瘤	详情
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (Shenzhen Xinpeng Biotech)		临床三期	深圳未名新鹏生物医药有限公司	肿瘤	详情
Dulanermin (Shanghai GeBaiDe)		临床三期	上海歌佰德生物技术有限公司	非小细胞肺癌	详情

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TRAIL R1