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 > 【TGF-beta RII】

TGF-beta RII信息

英文名称:Transforming growth factor beta receptor 2
中文名称:转化生长因子β受体2
靶点别称:NONHSAG034676,TGF-beta receptor type II,Transforming Growth Factor Beta Receptor 2,Transforming Growth Factor, Beta Receptor II Alpha,Transforming Growth Factor Beta Receptor Type IIC,Transforming growth factor-beta receptor type II,TbetaR-II,TGF-beta type II receptor,TGFBR2,Transforming Growth Factor, Beta Receptor II (70/80kDa),Transforming Growth Factor Beta Receptor II,TGFR-2,Transforming Growth Factor, Beta Receptor II Epsilon,Transforming Growth Factor, Beta Receptor II Delta,Transforming
上市药物数量:2
临床药物数量:2
最高研发阶段:临床二期

TGF-beta RII产品列表

 
评论(2)
TG2-H52H5|Human TGF-beta RII / TGFBR2 Protein, His Tag
  1. 857XXXXXXX13
  2. 0人赞
  3. I ordered Acro’s human TGF-beta Receptor II for Octet kinetics binding assays for several assays. Delivery was extremely quick and customer service was very responsive to questions I had. I first used this TGF-beta RII in an Octet binding kinetics assay and received high quality results that were consistent with what I expected. I also used this product as a TGF-beta sink in cytotoxicity assays. I have been impressed by the quality of Acro’s products.
  4. 2022-08-17
TG2-H52H5|Human TGF-beta RII / TGFBR2 Protein, His Tag
  1. 135XXXXXXX2
  2. 0人赞
  3. 用过很多次acro家的产品,这个蛋白用于细胞功能实验,活性好,实验内表现出非常好的活性和灵敏度。
  4. 2021-10-22
 

TGF-beta RII 分子别名

TGFBR2,TGFR2,TbetaR-II,TGFβR2

TGF-beta RII 分子背景

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

TGF-beta RII 前沿进展

TGF-beta RII上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

TGF-beta RII临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TASO-001 TASO-001; ATB-301 详情
IMC-TR1 IMC-TR1; LY-3022859 礼来制药 详情
Adoptive Cell Therapy (Oslo University Hospital) 奥斯陆大学医院 详情
YH-14618 P2K; YH14618; Peniel 2K; Peniel-2000 柳韩洋行株式会社 详情
HCW-9218 HCW-9218 临床二期 HCW Biologics Inc 实体瘤, 胰腺癌, 肺纤维化 详情

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