登录 | 注册    关注公众号  
搜索

Sonic Hedgehog信息

英文名称:Sonic Hedgehog Homolog
中文名称:SHH
靶点别称:HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC,Shh N-terminal processed signaling domains,ShhNp,ShhN,Sonic hedgehog protein,Sonic hedgehog protein N-product,Sonic Hedgehog Signaling Molecule,Sonic Hedgehog (Drosophila) Homolog
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Sonic Hedgehog产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SH7-H5229
Human
Human Sonic Hedgehog / Shh Protein, His Tag
 
评论(0)
 

Sonic Hedgehog 分子别名

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS

Sonic Hedgehog 分子背景

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog 前沿进展

Sonic Hedgehog临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IMP5471-CA 临床一期 上海瑛派药业有限公司 血液疾病 详情
ACC-006 ACC-006 临床二期 江苏艾迪药业股份有限公司, 中国药科大学 实体瘤, 非小细胞肺癌 详情
Sulforadex SFX-01 临床二期 Evgen Pharma, Lalilab, Pharmagra Labs 自闭症, 癌前状态, 蛛网膜下腔出血, 慢性肾功能不全, 帕金森病, 哮喘, 增生, 原位癌, 乳腺癌, 前列腺癌, 头颈癌, 心脏病, 神经发育障碍, 肿瘤, 精神分裂症, 间变, 头颈部鳞状细胞癌, 自闭症谱系障碍, 舒张期心力衰竭, 药物相关的副作用和不良反应 详情

消息提示

请输入您的联系方式,再点击提交!

确定