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Serpin A8信息

英文名称:Angiotensinogen
中文名称:血管紧张素
靶点别称:Angiotensinogen,Angiotensin I,Ang III,Angiotensin 3-8,Serpin A8,Angiotensin 2-8,Angiotensin 1-8,Angiotensin IV,Ang II,Angiotensin 1-10,Ang IV,Angiotensin II,Des-Asp[1]-angiotensin II,Alpha-1 Antiproteinase, Antitrypsin,ANHU,Fetal-Liver Predominant Transpo
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

Serpin A8产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
 
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Serpin A8 分子别名

Angiotensinogen,SerpinA8,AGT,ANHU

Serpin A8 分子背景

Serpin A8 also known as angiotensinogen (AGT) , is a member of the serpin family. It is an α-2-globulin that is expressed by the liver and secreted in plasma. As essential component of the renin-angiotensin system (RAS), Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III) in lowered blood pressure by the enzyme renin. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Defects in AGT are a cause of renal tubular dysgenesis (RTD).

Serpin A8 参考文献

Serpin A8临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ALN-AGT ALN-AGT01 临床一期 Alnylam Pharmaceuticals Inc 高血压, 先兆子痫 详情

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