Osteoprotegerin 靶点蛋白|抗体药物|临床药物信息

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在线 (2)

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Human (2)

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Protein (2)

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Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
TNB-H5220	Human	Human Osteoprotegerin / TNFRSF11B Protein, His Tag
TNB-H5259	Human	Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag

Osteoprotegerin 分子别名

TNFRSF11B,OCIF,OPG,Osteoprotegerin

Osteoprotegerin 分子背景

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

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Osteoprotegerin

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