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Nectin-1信息

英文名称:Pregnane X receptor
中文名称:孕烷X受体
靶点别称:SXR,Nuclear Receptor Subfamily 1, Group I, Member 2,Pregnane X Nuclear Receptor Variant 2,ONR1,PAR1,PAR2,PARq,BXR,PAR,PRR,SAR,Pregnane X Receptor,PXR,NR1I2,Nuclear Receptor Subfamily 1 Group I Member 2,Orphan Nuclear Receptor PXR,Steroid And Xenobiotic Receptor,Orphan Nuclear Receptor PAR1
上市药物数量:1
临床药物数量:2
最高研发阶段:批准上市

Nectin-1产品列表

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Nectin-1分子别名

PVRL1,Nectin-1,CD111,CLPED1,ED4,HIgR,HVEC,OFC7,PRR,PRR1,PVRR,PVRR1,SK-12

Nectin-1分子背景

Poliovirus receptor-related protein 1 (PVRL1) is also known as Herpes virus entry mediator C (HveC), Herpesvirus Ig-like receptor (HIgR), Nectin-1, CD antigen CD111, PVRL1 / Nectin-1 / CD111 belongs to the nectin family. PVRL1 / Nectin-1 is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM). PVRL1 is adhesion molecule found in a wide range of tissues. PVRL1 / Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4.

Nectin-1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Crotamiton/Diphenhydramine Hydrochloride/Vitamin E/Glycyrrhetinic Acid 克罗米通/盐酸苯海拉明/维生素E/甘草次酸 批准上市 安夫康 皮炎 详情

Nectin-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Vitamin E/Ascorbic Acid 临床三期 Advanced Medical Projects 脆性X染色体综合征, 神经痛 详情
Lidocaine/Allantoin/Glycyrrhetinic Acid/Vitamin E 临床二期 痔疮, 疣, 疼痛, 肛裂 详情

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