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MMP-9信息

英文名称:Matrix metalloproteinase 9
中文名称:基质金属蛋白酶-9
靶点别称:EC:3.4.24.35,EC 3.4.24,CLG4B,MMP9,Matrix Metallopeptidase 9,Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase),GELB,Matrix Metalloproteinase-9,92 KDa Type IV Collagenase,Macrophage Gelatinase,Type V Collagenase,Gelatina
上市药物数量:1
临床药物数量:3
最高研发阶段:临床二期

MMP-9产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
MM9-H5221
Human
Human MMP-9 Protein, His Tag (active enzyme)
 
评论(1)
MM9-H5221|Human MMP-9 Protein, His Tag (active enzyme)
  1. 183XXXXXXX3
  2. 0人赞
  3. 这个蛋白酶活效果不错,还很贴心的赠送了我一些激活剂APMA,还详细的给了我酶促的方案,最后我的实验也很顺利。
  4. 2021-09-24
 

MMP-9 分子别名

MMP9,CLG4B,GELB,MANDP2,Gelatinase B

MMP-9 分子背景

Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

MMP-9 前沿进展

MMP-9上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

MMP-9临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CALY-001 CALY-001 临床阶段不明 Calypso Biotech 炎症性肠疾病, 克罗恩病 详情
AQU-005 AQU-005; NMAQU-005; NM-AQU-005 临床一期 Aquilus Pharmaceuticals 神经痛 详情
DP-b99 DP-b99; DP-Bapta-99 临床二期 D-Pharm 脑缺血, 胰腺炎, 脑血管疾病, 中风 详情

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