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IL-2 R gamma信息

英文名称:Interleukin-2 receptor subunit gamma
中文名称:白介素-2受体γ亚基
靶点别称:Severe Combined Immunodeficiency,Interleukin 2 Receptor Subunit Gamma,Interleukin-2 Receptor Subunit Gamma,Common Cytokine Receptor Gamma Chain,P64,IL2RG,SCIDX,CD132 Antigen,GammaC,IL-2 Receptor Subunit Gamma,Cytokine Receptor Common Subunit Gamma,Interle
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

IL-2 R gamma Molecule Synonym Name

IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC

IL-2 R gamma 分子背景

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

IL-2 R gamma 参考文献

IL-2 R gamma临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TYF-IL-2Rg gene-modified autologous stem cells (Shenzhen Geno-Immune Medical Institute) 临床二期 深圳市免疫基因治疗研究院 x连锁联合免疫缺陷病 详情
THOR-707 THOR-707; SAR-444245 临床二期 Synthorx 实体瘤, 皮肤肿瘤, 间皮组织肿瘤, 鳞状细胞癌, 非小细胞肺癌, 黑色素瘤 详情

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