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IL-2 R gamma信息

英文名称:Interleukin-2 receptor subunit gamma
中文名称:白介素-2受体γ亚基
靶点别称:Common Cytokine Receptor Gamma Chain,IL-2R Subunit Gamma,IL2RG,SCIDX,CD132,CIDX,IL-2RG,IMD4,Nonfunctional Common Cytokine Receptor Gamma Chain,Combined Immunodeficiency, X-Linked,Interleukin 2 Receptor Subunit Gamma,Interleukin-2 Receptor Subunit Gamma,Severe Combined Immunodeficiency,Cytokine Receptor Common Subunit Gamma,CD132 Antigen,GammaC,Interleukin 2 Receptor, Gamma,IL-2 Receptor Subunit Gamma,SCIDX1,P64
上市药物数量:0
临床药物数量:11
最高研发阶段:临床二期

IL-2 R gamma产品列表

 
评论(1)
ILG-H85E8|Biotinylated Human IL-2 R gamma / CD132 Protein, His,Avitag™
  1. 150XXXXXXX1
  2. 1人赞
  3. 购买此款Avitag™ 的biotin的蛋白用于酵母筛选。酵母展示的抗体高亲和的同此蛋白结合。另外用这个蛋白进行酵母文库的MACS 富集,也得到预期的结果。
  4. 2022-02-21
 

IL-2 R gamma 分子别名

IL2RG,CD132,CIDX,IMD4,P64,SCIDX,SCIDX1,gammaC

IL-2 R gamma 分子背景

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

IL-2 R gamma 前沿进展

IL-2 R gamma临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
IAP-0971 IAP-0971 临床二期 盛禾(中国)生物制药有限公司 实体瘤, 肿瘤 详情
Simlukafusp alfa FAP-IL2v; RG-7461; aFAP-IL2v; RO-6874281; FAP-IL2v FP 临床二期 罗氏 头颈癌, 实体瘤, 食道癌, 肾细胞癌, 乳腺癌, 宫颈癌, 黑色素瘤 详情
MB-107 MB-107; IND-14570 临床二期 St Jude Children's Research Hospital, National Institute Of Allergy And Infectious Diseases (Niaid), 国家心肺和血液研究所, National Institute of Health, Islamabad x连锁联合免疫缺陷病, 免疫缺陷性疾病 详情
NL-201 (Neoleukin Therapeutics) NL-201 临床一期 Neoleukin Therapeutics Inc 实体瘤 详情
TYF-IL-2Rg gene-modified autologous stem cells (Shenzhen Geno-Immune Medical Institute) 临床二期 深圳市免疫基因治疗研究院 x连锁联合免疫缺陷病 详情
Recombinant human interleukin 15(Beijing Kawin) 临床一期 北京凯因科技股份有限公司 实体瘤 详情
REGN-7257 REGN-7257 临床二期 Regeneron Pharmaceuticals Inc 再生障碍性贫血 详情
TransCon IL-2 β/γ 临床二期 Ascendis Pharma A/S 实体瘤, 卵巢癌, 转移癌 详情
BJ-001(Boji Biomedical Technology) BJ-001 临床一期 博际生物医药科技(杭州)有限公司 实体瘤, 传染性疾病, 转移癌 详情
THOR-707 THOR-707; SAR-444245 临床二期 Synthorx Inc 结直肠癌, 肝细胞癌, 非小细胞肺癌, 转移癌, 黑色素瘤, 鳞状细胞癌, 咽肿瘤, 食管鳞状细胞癌, 口咽肿瘤, 肠道肿瘤, 间皮组织肿瘤, 霍奇金病, 皮肤肿瘤, 弥漫性大B-细胞淋巴瘤, 头颈部鳞状细胞癌, 胃癌, 头颈癌 详情
GI-101 SIM-323; SIM323; GI-101 临床二期 GI Innovation Inc 实体瘤, 肾细胞癌, 头颈部鳞状细胞癌, 肿瘤, 膀胱癌, 肉瘤, 转移癌, 黑色素瘤, 非小细胞肺癌 详情

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