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Frizzled-5信息

英文名称:Frizzled-5
中文名称:卷曲蛋白受体5
靶点别称:Frizzled Class Receptor 5,C2orf31,HFZ5,Frizzled 5, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 5,Fz-5,FzE5,Seven-Transmembrane Receptor Frizzled-5,Chromosome 2 Open Reading Frame 31,Frizzled (Drosophila) Homolog 5,HFz5
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

Frizzled-5产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
FZ5-H5259
Human
Human Frizzled-5 / FZD5 Protein, Fc Tag
 
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Frizzled-5 分子别名

FZD5,Frizzled-5,C2orf31,,Fz-5,hFz5,FzE5

Frizzled-5 分子背景

Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

Frizzled-5 前沿进展

Frizzled-5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Vantictumab OMP-18R5; anti-Fzd7 临床一期 Oncomed Pharmaceuticals Inc, 拜耳 实体瘤, 胰腺癌, 乳腺癌, 非小细胞肺癌 详情

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