Frizzled-2 靶点蛋白|抗体药物|临床药物信息

Frizzled-2信息

英文名称：Frizzled-2
中文名称：卷曲蛋白-2
靶点别称：Frizzled Class Receptor 2，Frizzled 2， Seven Transmembrane Spanning Receptor，Frizzled Family Receptor 2，FzE2，Fz-2

上市药物数量：0
临床药物数量：1
最高研发阶段：临床一期

Frizzled-2产品列表

筛选结果

产品库

在线 (2)

物种

Human (2)

标签

Fc Tag (2)

属性

Protein (2)

标记

Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
FZ2-H5251	Human	Human FZD2 /Frizzled-2 Protein, with C-Fc Tag
FZ2-H5255	Human	Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag

Frizzled-2 分子别名

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

Frizzled-2 分子背景

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Frizzled-2 前沿进展

Sagara N., et al., 1998, Biochem. Biophys. Res. Commun. 252:117-122.

Frizzled-2临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Vantictumab	OMP-18R5; anti-Fzd7	临床一期	Oncomed Pharmaceuticals Inc, 拜耳	实体瘤, 胰腺癌, 乳腺癌, 非小细胞肺癌	详情

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Frizzled-2