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FGF acidic信息

英文名称:Fibroblast growth factor 1
中文名称:成纤维细胞生长因子1
靶点别称:Acidic fibroblast growth factor,Heparin-binding growth factor 1,HBGF-1,Endothelial cell growth factor,FGF1,Fibroblast Growth Factor 1,Endothelial Cell Growth Factor, Alpha,Endothelial Cell Growth Factor, Beta,FGF-1,AFGF,FGFA,ECGF,Beta-Endothelial Cell Gro
上市药物数量:1
临床药物数量:1
最高研发阶段:批准上市

FGF acidic产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
AFF-H4116
Human
Human-aFGF-FGF-1-Protein
 
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FGF acidic 分子别名

FGF1,AFGF,ECGF,ECGF-beta,ECGFA,ECGFB,FGF-alpha,FGFA,GLIO703,HBGF1

FGF acidic 分子背景

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.

FGF acidic 参考文献

FGF acidic上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Pentosan Polysulfate Sodium 木聚硫钠 PPS; PZ-68; SP-54; AK-150 批准上市 Ivax, 梯瓦 Elmiron, Zilosul EU 间质性膀胱炎 Bene-Arzneimittel Gmbh 1996-09-26 疼痛, 间质性膀胱炎, 前列腺炎, 膝关节炎 详情

FGF acidic临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Muparfostat sodium PI-88 临床三期 澳洲国立大学 肝癌, 实体瘤, 前列腺癌, 肺癌, 肝细胞癌, 黑色素瘤, 非小细胞肺癌 详情

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