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Fas信息

英文名称:Apoptosis-mediating surface antigen FAS
中文名称:Fas抗原
靶点别称:Tumor Necrosis Factor Receptor Superfamily, Member 6,Apo-1 antigen,CD95,APT1,FAS1,TNFRSF6,FAS,Fas Cell Surface Death Receptor,Fas (TNF Receptor Superfamily, Member 6),Apoptosis-Mediating Surface Antigen FAS,TNF Receptor Superfamily Member 6,FASLG Receptor,CD95 Antigen,Mutant Tumor Necrosis Receptor Superfamily Member 6,Tumor Necrosis Factor Receptor Superfamily Member 6,Apoptosis Signaling Receptor FAS,APO-1 Cell Surface Antigen,Apoptosis Antigen 1,Fas AMA,ALPS1A,APO-1,FASTM,fas Receptor
上市药物数量:1
临床药物数量:2
最高研发阶段:批准上市

Fas产品列表

产品库
物种
属性
 
评论(1)
FAS-H5252|Human Fas / TNFRSF6 / CD95 Protein, Fc Tag (MALS verified)
  1. 182XXXXXXX2
  2. 3人赞
  3. 这个FAS蛋白也是TNF家族的,我用来测定与FASL的Fortebio实验,做出来结果很好,R2可以有0.996。
  4. >
  5. 2019-10-10
 

Fas 分子别名

FAS,ALPS1A,APO1,APT1,CD95,FAS1,FASTM,TNFRSF6,FasR

Fas 分子背景

The Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.

Fas 前沿进展

Fas上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Kanglaite 批准上市 浙江康莱特药业有限公司 Kanglaite Mainland China 肝癌, 非小细胞肺癌 Zhejiang Kanglaite Pharmaceutical Co Ltd 1997-01-01 实体瘤, 肝癌, 前列腺癌, 非小细胞肺癌 详情

Fas临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
APO-010 APO-010 临床二期 Onxeo Sa 肿瘤, 多发性骨髓瘤 详情
ONL-1204 ONL-1204 临床一期 Onl Therapeutics 开角型青光眼, 视网膜脱离, 地图状萎缩 详情

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