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Complement Factor D信息

英文名称:Complement factor D
中文名称:补体因子D
靶点别称:EC 3.4.21,EC 3.4.21');,C3 Convertase Activator,ADIPSIN,D Component Of Complement (Adipsin),PFD,Complement Factor D Preproprotein,Complement Factor D (Adipsin),EC 3.4.21.46,ADN,CFD,Properdin factor D,DF,Complement factor D,EC:3.4.21.46
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

Complement Factor D 分子别名

CFD,Adipsin,PFD,DF,Complement factor D

Complement Factor D 分子背景

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Complement Factor D 前沿进展

Complement Factor D临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ACH-5548 ACH-5548; ACH-0145548 临床一期 Achillion Pharmaceutical 自身免疫疾病 详情
BCX-9930 BCX-9930 临床二期 Biocryst Pharmaceuticals 阵发性血红蛋白尿症, 免疫球蛋白a肾病, 膜性肾小球肾炎, 肾小球肾炎 详情
Danicopan ACH-4471; ACH-0144471; ALXN-2040 临床三期 Achillion Pharmaceutical 阵发性血红蛋白尿症, 肾功能不全, 膜增生性肾小球肾炎, 地图状萎缩, 肝功能衰退, 肾小球肾炎 详情
ACH-5228 ACH-0145228; ACH-5228; ALXN-2050 临床二期 Achillion Pharmaceutical 重症肌无力, 阵发性血红蛋白尿症, 免疫球蛋白a肾病, 肾脏疾病, 狼疮肾炎 详情

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