Complement Factor D 靶点蛋白|抗体药物|临床药物信息

Complement Factor D信息

英文名称：Complement factor D
中文名称：补体因子D
靶点别称：EC 3.4.21，EC 3.4.21');，C3 Convertase Activator，ADIPSIN，D Component Of Complement (Adipsin)，PFD，Complement Factor D Preproprotein，Complement Factor D (Adipsin)，EC 3.4.21.46，ADN，CFD，Properdin factor D，DF，Complement factor D，EC:3.4.21.46

上市药物数量：0
临床药物数量：5
最高研发阶段：临床三期

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Protein (5)

标记

Unconjugated (5)

货号	物种	产品描述
CFD-H5256	Human	Human Complement Factor D / CFD Protein, Fc Tag
CFD-H52H8	Human	Human Complement Factor D / CFD Protein, His Tag (active enzyme)
CFD-M52H3	Mouse	Mouse Complement Factor D / CFD Protein, His Tag
CFD-R5255	Rhesus macaque	Rhesus macaque Complement Factor D / CFD Protein, Fc Tag
CFD-R52H3	Rhesus macaque / Cynomolgus	Rhesus macaque / Cynomolgus Complement Factor D / CFD Protein, His Tag (active enzyme)

CFD-H52H8|Human Complement Factor D / CFD Protein, His Tag (active enzyme)

158XXXXXXX8

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2023-01-07

Complement Factor D 分子别名

CFD,Adipsin,PFD,DF,Complement factor D

Complement Factor D 分子背景

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Complement Factor D 前沿进展

Complement Factor D临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
BCX-9930	BCX-9930	临床二期	Biocryst Pharmaceuticals Inc	阵发性血红蛋白尿症, 免疫球蛋白a肾病, 膜性肾小球肾炎, 肾小球肾炎	详情
ACH-5548	ACH-5548; ACH-0145548	临床一期	Achillion Pharmaceuticals Inc	自身免疫疾病	详情
ALXN-2080	ALXN-2080	临床一期	Alexion Pharmaceuticals Inc		详情
Vemircopan	ACH-0145228; ACH-5228; ALXN-2050	临床二期	Achillion Pharmaceuticals Inc	重症肌无力, 免疫球蛋白a肾病, 阵发性血红蛋白尿症, 肾脏疾病, 狼疮肾炎, 肝功能衰退	详情
Danicopan	ACH-4471; ACH-0144471; ALXN-2040	临床三期	Achillion Pharmaceuticals Inc	阵发性血红蛋白尿症, 肾功能不全, 新型冠状病毒肺炎, 膜增生性肾小球肾炎, 地图状萎缩, 肝功能衰退, 肾小球肾炎	详情

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Complement Factor D