CD34 靶点蛋白|抗体药物|临床药物信息

CD34信息

英文名称：Hematopoietic progenitor cell antigen CD34
中文名称：造血祖细胞抗原CD34
靶点别称：CD34，CD34 Molecule，CD34 Antigen，Hematopoietic Progenitor Cell Antigen CD34，Antigens， CD34

上市药物数量：1
临床药物数量：13
最高研发阶段：批准上市

CD34产品列表

筛选结果

产品库

在线 (1)

物种

Human (1)

标签

His Tag (1)

属性

Protein (1)

标记

Unconjugated (1)

货号	物种	产品描述	蛋白结构	纯度	活性
CD4-H52H9	Human	Human CD34 Protein, His Tag

CD34 分子别名

CD34,RP11-328D5.2

CD34 分子背景

CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. As a ~ 110 kDa monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.

CD34 前沿进展

CD34上市药物信息

英文名称	中文名称	研发代码	研发阶段	公司	最早商品名	最早批准国家	最早适应症	最早批准公司	最早批准日期	适应症	临床试验
Anti-CD34 mab-sirolimus (OrbusNeich)			批准上市	Orbusneich			冠状动脉再狭窄	Orbusneich	2013-01-01	冠状动脉病变, 冠状动脉再狭窄	详情

CD34临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Autologous CD34+-enriched hematopoietic stem and progenitor cells (Genenta Science)		临床二期	Genenta Science Srl	胶质母细胞瘤, 多发性骨髓瘤	详情
Lentiviral vector transduced CD34+ cells Therapy		临床二期	Great Ormond Street Hospital For Children Nhs Foundation Trust	慢性肉芽肿病	详情
CLBS-12	CLBS-12	临床二期	Caladrius Biosciences Inc	动脉粥样硬化, 闭塞性血栓性脉管炎, 缺血	详情
Alpha-galactosidase A stem cell therapy (University Health Network/Ozmosis)		临床一期	University Health Network	法布里病	详情
Autologous peripheral blood stem cell therapy (CellProthera)		临床二期	Cellprothera	心肌梗塞	详情
GSK-2696277	GSK-2696277; OTL-300	临床二期	葛兰素史克, Ospedale San Raffaele, Fondazione Telethon	β-地中海贫血	详情
Stem cell therapeutics (ExCellThera)	ECT-002; ECT-003; ECT-005; UM171 + UM092; UM171 + UM390	临床二期	Excellthera Inc	血液肿瘤, 多发性骨髓瘤, 急性髓细胞样白血病	详情
Autologous CD34+ cells transduced with a lentiviral vector containing the human SGSH gene (Orchard)	OTL-201	临床二期	The University Of Manchester	Ⅲ型黏多糖贮积症	详情
shRNA-Modified CD34 Cell Therapy		临床一期	康霖生物科技（杭州）有限公司	HIV感染	详情
Retroviral ADA-transduced CD34+ cells (NHGRI/UCLA)		临床二期	Ucla Biomedical Library	腺苷脱氨酶缺乏	详情
CD34+ bone marrow stem cells (University of California)		临床二期	加利福尼亚大学戴维斯分校	色素性视网膜炎, 糖尿病视网膜病变, 年龄相关性黄斑变性, 视网膜静脉阻塞	详情
Donor-derived CD34+ HSC with CRISPR/Cas9-mediated CD33 deletion(German Cancer Research Center)		临床一期	German Cancer Research Center (Dkfz)	急性髓细胞样白血病	详情
Cord blood stem cells(Tatcitus Therapeutics/Mount Sinai Health System)	HSC-100	临床一期	Icahn School Of Medicine At Mount Sinai, Tatcitus Therapeutics	白血病, 血液肿瘤, 霍奇金病, 骨髓增生异常综合征, 急性淋巴细胞白血病, 非霍奇金淋巴瘤	详情

会议日历

会议一览

CD34