登录 | 注册    关注公众号  
搜索
 > 【CD34】

CD34信息

英文名称:Hematopoietic progenitor cell antigen CD34
中文名称:造血祖细胞抗原CD34
靶点别称:CD34,CD34 Molecule,CD34 Antigen,Hematopoietic Progenitor Cell Antigen CD34,Antigens, CD34
上市药物数量:1
临床药物数量:13
最高研发阶段:批准上市

CD34产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CD4-H52H9
Human
Human CD34 Protein, His Tag
 
评论(0)
 

CD34 分子别名

CD34,RP11-328D5.2

CD34 分子背景

CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. As a ~ 110 kDa monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.

CD34 前沿进展

CD34上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Anti-CD34 mab-sirolimus (OrbusNeich) 批准上市 Orbusneich 冠状动脉再狭窄 Orbusneich 2013-01-01 冠状动脉再狭窄 详情

CD34临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
shRNA-Modified CD34 Cell Therapy 临床一期 康霖生物科技(杭州)有限公司 HIV感染 详情
Cord blood stem cells(Tatcitus Therapeutics/Mount Sinai Health System) HSC-100 临床一期 Icahn School Of Medicine At Mount Sinai, Tatcitus Therapeutics 血液肿瘤, 白血病, 霍奇金病, 骨髓增生异常综合征, 急性淋巴细胞白血病, 非霍奇金淋巴瘤 详情
Lentiviral vector transduced CD34+ cells Therapy 临床二期 Great Ormond Street Hospital For Children Nhs Foundation Trust 慢性肉芽肿病 详情
Alpha-galactosidase A stem cell therapy (University Health Network/Ozmosis) 临床一期 University Health Network 法布里病 详情
Retroviral ADA-transduced CD34+ cells (NHGRI/UCLA) 临床二期 Ucla Biomedical Library 腺苷脱氨酶缺乏 详情
Autologous CD34+-enriched hematopoietic stem and progenitor cells (Genenta Science) Genenta Science 详情
Autologous peripheral blood stem cell therapy (CellProthera) Cellprothera 详情
Alecmestencel-T (Apceth) Apceth Gmbh & Co Kg 详情
γ-globin gene therapy (CSL Behring) CSL-200 美国杰特贝林生物制品有限公司 详情
CLBS-12 CLBS-12 Caladrius Biosciences 详情
Autologous stem cell therapy (Shire) Shire Development Llc 详情
Dilanubicel (Nohla Therapeutics) NLA-101 弗莱德哈钦森癌症研究中心 详情
Stem cell therapeutics (ExCellThera) ECT-002; ECT-003; ECT-005; UM171 + UM092; UM171 + UM390 临床二期 Excellthera Inc 血液肿瘤, 多发性骨髓瘤, 急性髓细胞样白血病 详情
GSK-2696277 GSK-2696277; OTL-300 临床二期 葛兰素史克, Ospedale San Raffaele, Fondazione Telethon β-地中海贫血 详情

消息提示

请输入您的联系方式,再点击提交!

确定