Carbonic Anhydrase IX 靶点蛋白|抗体药物|临床药物信息

Carbonic Anhydrase IX信息

英文名称：Carbonic anhydrase IX
中文名称：碳酸酐酶IX
靶点别称：EC:4.2.1.1，Renal cell carcinoma-associated antigen G250，P54/58N，CA9，Carbonic Anhydrase 9，RCC-Associated Protein G250，Carbonate Dehydratase IX，Carbonic Dehydratase，CA-IX，CAIX，PMW1，MN，EC 4.2.1.1，G250，Carbonic anhydrase IX，Membrane antigen MN，RCC-associated antigen G250

上市药物数量：0
临床药物数量：6
最高研发阶段：临床二期

Carbonic Anhydrase IX产品列表

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Protein (10)

标记

货号	物种	产品描述
CA9-H5220	Human	Human Carbonic Anhydrase IX / CA9 (138-414) Protein, His Tag (MALS verified)
CA9-H5226	Human	Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (active enzyme, MALS verified)
CA9-H82E3	Human	Biotinylated Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His,Avitag™ (MALS verified)
CA9-H5253	Human	Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc Tag (MALS verified)
CA9-M52H3	Mouse	Mouse Carbonic Anhydrase IX / CA9 (32-390) Protein, His Tag (MALS verified)
CA9-C82E6	Cynomolgus	Biotinylated Cynomolgus Carbonic Anhydrase IX / CA9 (38-398) Protein, His,Avitag™ (MALS verified)
CA9-HP2H6	Human	PE-Labeled Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag (Site-specific conjugation)
CA9-HF228	Human	FITC-Labeled Human Carbonic Anhydrase IX / CA9 (38-414) Protein, His Tag
CA9-H82F5	Human	Biotinylated Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc,Avitag™ (MALS verified)
CA9-C52H3	Cynomolgus	Cynomolgus Carbonic Anhydrase IX Protein, His Tag (MALS verified)

CA9-H5253|Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc Tag (MALS verified)

173XXXXXXX1

4人赞

蛋白用来做药物筛选，纳米抗体。我们课题组都购买的acro产品，质量不错，比较稳定。我们一直在用，不过产品种类不多。有待覆盖更多类型产品。
2022-01-07

CA9-H5220|Human Carbonic Anhydrase IX / CA9 (138-414) Protein, His Tag (MALS verified)

139XXXXXXX3

4人赞

到货速度很快，抗原包装完好，溶解方法描述清晰，溶解方法简单，溶解度很好，进行实验非常顺利，质量有保障，买了很多次，质量始终如一
2022-01-05

CA9-H5253|Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc Tag (MALS verified)

139XXXXXXX3

4人赞

用于抗体筛选的监测工作，目前方法建立顺利进行中，提供的技术支持也比较完善，试验中出现的问题都能给予多方面的支持
2021-07-13

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Carbonic Anhydrase IX 分子别名

CAIX,CA9,CA-IX,G250,MN,P54,58N,pMW1

Carbonic Anhydrase IX 分子背景

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct CA families (α, β, γ, δ and ε). Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family. CA9 / CAIX with an optimal activity at pH 6.49. Reversible hydration of carbon dioxide. CA IX participates in pH regulation. CA9 may be involved in the control of cell proliferation and transformation. CA-IX appears to be a novel specific biomarker for a cervical neoplasia.

Carbonic Anhydrase IX 前沿进展

Carbonic Anhydrase IX临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Girentuximab-Zr-89	TLX250-CDx; 89Zr-TX250; TLX-250-CDx; 89Zr-TX-250	临床二期	Wilex	膀胱癌, 肝细胞癌, 宫颈癌, 非小细胞肺癌, 胰腺导管癌, 结直肠癌, 肉瘤, 鼻咽癌, 胆管上皮癌, 造影剂, 肾细胞癌, 胶质母细胞瘤, 小细胞肺癌, 卵巢上皮癌, 尿路上皮癌, 三阴性乳腺癌, 食道癌, 胃癌, 头颈部鳞状细胞癌	详情
Indium-111-DOTA-girentuximab-IRDye800CW (Radboud University)		临床一期	Radboud University Nijmegen	肾细胞癌, 诊断剂	详情
Girentuximab	MAb-G250; cG250; WX-G250	临床一期	Wilex	肾肿瘤, 肾细胞癌	详情
Sulfamide-nitroimidazole		临床阶段不明	Dualtpharma	肿瘤	详情
PMI-05	PMI-05	临床一期	Precision Molecular	肿瘤	详情
Lutetium-177 DOTA girentuximab	TLX-250	临床二期	Wilex, Heidelberg, Telix Pharmaceuticals Ltd	肾细胞癌, 肿瘤	详情

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Carbonic Anhydrase IX