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Carbonic Anhydrase IX信息

英文名称:Carbonic anhydrase IX
中文名称:碳酸酐酶IX
靶点别称:EC:4.2.1.1,Renal cell carcinoma-associated antigen G250,P54/58N,CA9,Carbonic Anhydrase 9,RCC-Associated Protein G250,Carbonate Dehydratase IX,Carbonic Dehydratase,CA-IX,CAIX,PMW1,MN,EC 4.2.1.1,G250,Carbonic anhydrase IX,Membrane antigen MN,RCC-associated
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

Carbonic Anhydrase IX产品列表

 
评论(1)
CA9-H5253|Human Carbonic Anhydrase IX / CA9 (38-414) Protein, Fc Tag (MALS verified)
  1. 139XXXXXXX3
  2. 0人赞
  3. 用于抗体筛选的监测工作,目前方法建立顺利进行中,提供的技术支持也比较完善,试验中出现的问题都能给予多方面的支持
  4. 2021-07-13
 

Carbonic Anhydrase IX 分子别名

CAIX,CA9,CA-IX,G250,MN,P54,58N,pMW1

Carbonic Anhydrase IX 分子背景

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. There are at least five distinct CA families (α, β, γ, δ and ε). Carbonic anhydrase 9 (CA9 / CAIX) is also known as Membrane antigen MN (MN), Renal cell carcinoma-associated antigen G250, which belongs to the alpha-carbonic anhydrase family. CA9 / CAIX with an optimal activity at pH 6.49. Reversible hydration of carbon dioxide. CA IX participates in pH regulation. CA9 may be involved in the control of cell proliferation and transformation. CA-IX appears to be a novel specific biomarker for a cervical neoplasia.

Carbonic Anhydrase IX 参考文献

Carbonic Anhydrase IX临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PMI-05 PMI-05 临床一期 Precision Molecular 肿瘤 详情
Sulfamide-nitroimidazole 临床阶段不明 Dualtpharma 肿瘤 详情
Indium-111-DOTA-girentuximab-IRDye800CW (Radboud University) 临床一期 Radboud University Nijmegen 肾细胞癌, 诊断剂 详情
Lutetium-177 DOTA girentuximab 临床二期 Wilex, Heidelberg, Telix Pharmaceuticals 肾细胞癌 详情

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