登录 | 注册    关注公众号  
微信公众号
搜索

LRRK2信息

英文名称:Leucine-rich repeat serine/threonine-protein kinase 2
中文名称:富含亮氨酸重复的丝氨酸/苏氨酸蛋白激酶-2
靶点别称:PARK8,LRRK2,Leucine Rich Repeat Kinase 2,Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2,Parkinson Disease (Autosomal Dominant) 8,Augmented In Rheumatoid Arthritis 17,Dardarin,AURA17,RIPK7,ROCO2,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2,DKFZp434H2111,FLJ45829
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

LRRK2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
LK2-H5243
Human
Human LRRK2 Protein, His Tag
LK2-H5245
Human
Human LRRK2 (G2019S) Protein, His Tag
 
评论(0)
 

LAMP5 分子别名

LAMP5 分子背景

LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions. LAMP5 is expressed highly and specifically in MLL-r leukemia. LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP-5 is a novel modulator of innateimmune pathways in MLL-r leukemias. Downregulation of LAMP5 led to inhibition of NF-κB signaling and increased activation of type-1 interferon signaling downstream of Toll-like Receptor/Interleukin 1 Receptor activation.

LAMP5 前沿进展

LRRK2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VRN-01 VRN-01 临床一期 Voronoi 胰腺癌, 乳腺癌 详情
DNL-201 DNL-201 罗氏 详情
BIIB-094 BIIB-094; ION-859; IONIS-BIIB7Rx 临床二期 百健 帕金森病 详情
DNL-151 BIIB-122; DNL-151 临床三期 百健, 罗氏 帕金森病 详情
WXWH0226 WXWH0226; WXWH-0226 临床一期 贵州伊诺其尼科技有限公司 帕金森病 详情

消息提示

请输入您的联系方式,再点击提交!

确定