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TDP-43产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
TD3-H5145
Human
Human TDP-43 Protein, His Tag
 
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TDP-43 分子别名

TAR DNA-binding protein 43

TDP-43 分子背景

TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.

TDP-43 前沿进展

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