Annexin A5 靶点蛋白|抗体药物|临床药物信息

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Protein (2)

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Unconjugated (2)

货号	物种	产品描述	蛋白结构	纯度	活性
AN5-H5123	Human	Human Annexin A5 Protein, His Tag
AN5-H5118	Human	Human Annexin A5 Protein, Tag Free

Annexin A5 分子别名

ANXA5,ANX5,ENX2,PP4,Annexin V,Annexin A5

Annexin A5 分子背景

Anexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Anexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Anexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Anexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).

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