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Glucosylceramidase信息

英文名称:Glucosylceramidase
中文名称:葡糖苷酰鞘氨醇酶
靶点别称:Glucosylceramidase
上市药物数量:0
临床药物数量:0
最高研发阶段:临床前

Glucosylceramidase产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GLE-H52H3
Human
Human Glucosylceramidase Protein, His Tag
 
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Glucosylceramidase 分子别名

Glucosylceramidase,GBA,Acid beta-glucosidase,Alglucerase,beta-glucocerebrosidase,D-glucosyl-N-acylsphingosine glucohydrolase,EC 3.2.1.45,GBA,GBA1,GC,GCB,GLUC,glucosidase, beta, acid,glucosidase, beta,acid (includes glucosylceramidase),Glucosylceramidase,I

Glucosylceramidase 分子背景

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, it plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides,it participates in the PKC-activated salvage pathway of ceramide formation and plays a role in cholesterol metabolism. It may either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. Defects in Glucosylceramidase are the cause of Gaucher disease, also known as glucocerebrosidase deficiency. Gaucher disease is the most prevalent lysosomal storage disease, characterized by accumulation of glucosylceramide in the reticulo-endothelial system. Currently, enzyme replacement therapy is used to treat patients with the disease.

Glucosylceramidase 前沿进展

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