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SIRP alphaV2信息

英文名称:Signal-regulatory protein alpha
中文名称:信号调节蛋白α
靶点别称:SHPS-1,Macrophage fusion receptor,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,CD172a,MyD-1 antigen,Sirp-alpha-3,MYD1,SIRPA,Signal Regulatory Protein Alpha,CD172 Antigen-Like Family Member A,Inhibitory Receptor SHPS-1,PTPNS1,SHPS1,SIRP,P84,Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs,Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1,Tyrosine-Protein Phosphatase Non-Recept
上市药物数量:2
临床药物数量:10
最高研发阶段:批准上市

SIRP alphaV2产品列表

 
评论(7)
SI2-H82W8|Biotinylated Human SIRP alphaV2 / CD172a Protein, His,Avitag™
  1. 177XXXXXXX7
  2. 0人赞
  3. 每次买蛋白都是在acro,这次购买human-bio-cd172aV2,用于检测抗体间表位竞争关系。
  4. >
  5. 2021-11-24
SI2-H52H9|Human SIRP alphaV2 / CD172a Protein, His Tag
  1. 177XXXXXXX7
  2. 0人赞
  3. 人源CD172a抗原,带HIS标签,octect仪器使用proA传感器结合抗原,检测抗体抗原结合强弱,筛选抗体。
  4. >
  5. 2021-11-10
SI2-H82W8|Biotinylated Human SIRP alphaV2 / CD172a Protein, His,Avitag™
  1. 152XXXXXXX0
  2. 0人赞
  3. 我们公司购买了Biotinylated Mouse SIRP alpha / CD172a Protein, His,Avitag™,主要目的是为了做免疫,从流式结果来看,还是不错的,已经反复试验过了,物流速度也很快,说明书很详细,销售人员也很专业。
  4. 2022-01-20
 

SIRP alphaV2 分子别名

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

SIRP alphaV2 分子背景

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alphaV2 前沿进展

SIRP alphaV2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Relugolix/Estradiol/Norethindrone Acetate 批准上市 Myovant Sciences MYFEMBREE United States 疼痛, 子宫内膜异位症 Myovant Sciences 2021-05-26 疼痛, 子宫内膜异位症, 平滑肌瘤, 子宫肿瘤, 月经过多 详情
Elagolix/estradiol/norethindrone acetate 批准上市 艾伯维 Oriahnn United States 月经过多 Abbvie Inc 2020-05-29 月经过多 详情

SIRP alphaV2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
BR-105 BR105 临床一期 海正生物制药有限公司, 浙江博锐生物制药有限公司 肿瘤 详情
ELA-026 ELA-026 临床一期 Electra Therapeutics Inc 噬血细胞性淋巴组织细胞增多症 详情
Anzurstobart CC-95251; BMS-986351 临床一期 Celgene Corp 骨髓增生异常综合征, 急性髓细胞样白血病 详情
BI-765063 OSE-172; BI-765063 临床一期 Ose Immunotherapeutics 实体瘤, 头颈部鳞状细胞癌, 结直肠癌, 非小细胞肺癌, 黑色素瘤 详情
AL-008 AL-008; IBI-397 临床一期 Alector 肿瘤 详情
IBC-0966 IBC-0966 临床二期 盛禾(中国)生物制药有限公司 肿瘤 详情
TQB-2928 TQB-2928 临床一期 正大天晴药业集团股份有限公司 血液肿瘤, 实体瘤, 肿瘤 详情
[89Zr]Zr- BI-765063(Boehringer Ingelheim) 临床一期 Boehringer Ingelheim Corp 头颈部鳞状细胞癌, 黑色素瘤, 非小细胞肺癌 详情
RRx-001 ABDNAZ; RRx-001 临床三期 Epicentre Biotechnologies Llc 胆管上皮癌, 口腔炎, 非小细胞肺癌, 转移癌, 脑转移, 小细胞癌, 淋巴瘤, 结直肠癌, 脑癌, 实体瘤, 中枢神经系统肿瘤, 神经内分泌瘤, 少突神经胶质瘤, 肿瘤, 卵巢上皮癌, 胶质母细胞瘤, 小细胞肺癌 详情

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