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 > 【Integrin alpha M beta 2】

Integrin alpha M beta 2信息

英文名称:Integrin alpha-M/beta-2
中文名称:整合素α-M/β-2复合体
靶点别称:Macrophage-1 Antigen
上市药物数量:0
临床药物数量:0
最高研发阶段:终止

Integrin alpha M beta 2 分子别名

Integrin alpha M beta 2,ITGAM&ITGB2

Integrin alpha M beta 2 分子背景

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.

Integrin alpha M beta 2 前沿进展

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