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EphA2信息

英文名称:Ephrin type-A receptor 2
中文名称:A型肝配蛋白受体-2
靶点别称
上市药物数量:2
临床药物数量:3
最高研发阶段:批准上市

EphA2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
EP2-H52H4
Human
Human EphA2 Protein, His Tag (MALS verified)
 
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EphA2 分子别名

EphA2

EphA2 分子背景

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

EphA2 前沿进展

EphA2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

EphA2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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