描述/背景(Background)
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling.
种属(Host Species)
Mouse
克隆号(Clone)
4C4
适用方法(Application)
IHC
效价(Property)
1:500
状态(State)
Liquid
阳性对照(Positive Control)
Human Tonsil Tissues
克隆类型(Clonality)
Monoclonal
分子别名(Synonym)
CD45R
研究领域(Research Field)
Cancer Drug Targets
抗体来源(Source)
Mouse
同种型(Isotype)
IgG
储存(Storage)
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
典型数据(Typical Data)
质控样本(Control Sample)
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HGS-S248 at 1/500 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本(Cancer Sample)
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S248 at 1/500 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.