Recombinant Proteins iso9001 ISO13485
搜索
 >  其他蛋白>R-Spondin 3 >RS3-H5253

Human R-Spondin 3 / RSPO3 Protein, Fc Tag

此产品为在研产品。如果您对此产品有兴趣,请直接联系我们。我们会根据您的需求相应地加速我们的研发进程,并为您进行产品预留。

分子别名(Synonym)

RSPO3,CRISTIN1,PWTSR,THSD2

表达区间及表达系统(Source)

Human R-Spondin 3 Protein, Fc Tag (RS3-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - His 272 (Accession # Q9BXY4-1).

蛋白结构(Molecular Characterization)

Online-Res(Gln 22 - His 272) Q9BXY4-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 55 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.

 

前沿进展

 
货号/价格
开发建议 点击预购
文档
联系电话:
400-682-2521(全国)
010-57737274(北京)
021-26136428(上海)
运输方式
订单邮箱:
order.cn@acrobiosystems.com
技术支持邮箱:
techsupport@acrobiosystems.com
R-Spondin 3靶点信息
英文全称:R-spondin-3
中文全称:R-脊椎蛋白3
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:0详情
最高研发阶段:无进展
查看更多信息
推荐会议
查看全部会议

消息提示

请输入您的联系方式,再点击提交!

确定