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GFR alpha-like产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
GFA-H52H3
Human
Human GFR alpha-like Protein, His Tag
 
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GFR alpha-like Molecule Synonym Name

GFR alpha like,GFR alpha-like,GFRAL,GRAL

GFR alpha-like 分子背景

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

GFR alpha-like 参考文献

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