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 > 【CD47】重组蛋白信息

CD47信息

英文名称:Cluster of Differentiation 47
中文名称:分化群47
靶点别称:Protein MER6,Integrin-associated protein,Antigenic surface determinant protein OA3,Leukocyte surface antigen CD47,CD47,MER6,CD_antigen: CD47
上市药物数量:0
临床药物数量:5
最高研发阶段:临床二期

CD47产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD7-H82F6
Human
Biotinylated Human CD47 Protein, Fc Tag
CD7-C5252
Cynomolgus / Rhesus macaque
Cynomolgus CD47 Protein, Fc Tag
CD7-H5227
Human
Human CD47 Protein
CD7-H5256
Human
Recombinant Human CD47 Protein
CD7-H52A5
Human
Human CD47 Protein, mouse IgG2a Fc Tag
CD7-M5251
Mouse
Mouse CD47 Protein, Fc Tag
CD7-R5256
Rat
Rat CD47 Protein, Fc Tag
CD7-R5257
Rabbit
Rabbit CD47 Protein, Fc Tag
CD7-H82E9
Human
Avitag™ Biotinylated Human CD47, His Tag
CD7-HA2E9
Human
Unconjugated Human CD47 Protein, His Tag & Avi Tag
CD7-C52H1
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque CD47, His Tag
CD7-M522b
Mouse
Mouse CD47 Protein
CD7-M525a
Mouse
Mouse CD47 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5251
Human
Human CD47 Protein, Llama IgG2b Fc Tag, low endotoxin
CD7-H522a
Human
Human CD47 Protein, low endotoxin

CD47 分子别名

CD47,MER6,IAP,OA3

CD47 分子背景

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

CD47 参考文献

CD47临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TTI-622 TTI-622 临床一期 Trillium Therapeutics Inc 多发性骨髓瘤, 淋巴瘤
ALX-148 ALX-148; ALX148 临床一期 Alexo Therapeutics 实体瘤, 非霍奇金淋巴瘤 详情
CC-90002 CC-90002; INBRX-103 临床一期 Inhibrx, 新基 骨髓增生异常综合征, 急性骨髓性白血病 详情
TTI-621 TTI-621 临床一期 The Hospital for Sick Children, University Health Network, Trillium Therapeutics Inc 血液系统恶性肿瘤, 实体瘤, 蕈样真菌病 详情
SRF-231 SRF-231 临床一期 Surface Oncology 血液系统恶性肿瘤, 实体瘤 详情
Hu5F9-G4 Hu5F9-G4 临床二期 斯坦福大学, Forty Seven 实体瘤, 急性骨髓性白血病 详情

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