搜索
 > 【CD47】重组蛋白信息

CD47信息

英文名称:Cluster of Differentiation 47
中文名称:分化群47
靶点别称:Protein MER6,Integrin-associated protein,Antigenic surface determinant protein OA3,Leukocyte surface antigen CD47,CD47,MER6,CD_antigen: CD47
上市药物数量:0
临床药物数量:5
最高研发阶段:临床二期

CD47 分子别名

CD47,MER6,IAP,OA3

CD47 分子背景

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

CD47 参考文献

CD47临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
TTI-622 TTI-622 临床一期 Trillium Therapeutics Inc 多发性骨髓瘤, 淋巴瘤
ALX-148 ALX-148; ALX148 临床一期 Alexo Therapeutics 实体瘤, 非霍奇金淋巴瘤 详情
CC-90002 CC-90002; INBRX-103 临床一期 Inhibrx, 新基 骨髓增生异常综合征, 急性骨髓性白血病 详情
TTI-621 TTI-621 临床一期 The Hospital for Sick Children, University Health Network, Trillium Therapeutics Inc 血液系统恶性肿瘤, 实体瘤, 蕈样真菌病 详情
SRF-231 SRF-231 临床一期 Surface Oncology 血液系统恶性肿瘤, 实体瘤 详情
Hu5F9-G4 Hu5F9-G4 临床二期 斯坦福大学, Forty Seven 实体瘤, 急性骨髓性白血病 详情

消息提示

请输入您的联系方式,再点击提交!

确定