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CA125信息

英文名称:Mucin-16
中文名称:粘蛋白-16
靶点别称:Mucin-16,CA125,Ovarian carcinoma antigen CA125,CA-125,MUC16,MUC-16,Ovarian cancer-related tumor marker CA125
上市药物数量:0
临床药物数量:5
最高研发阶段:撤市

CA125产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CA5-H82F4
Human
Biotinylated Human CA125 / MUC16 Protein, Fc,Avitag
 
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CA125 Molecule Synonym Name

CA125,CA-125,CA125MUC-16,FLJ14303,MUC16,mucin 16,mucin-16

CA125 分子背景

The CA125, also known as the MUC16, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. The CA 125 molecule is almost certainly a glycoprotein with a predominance of O-linkages. It is heterogeneous with regard to both size and charge, most likely due to continuous deglycosylation of side chains during its life-span in bodily fluids. It exists as a very large complex (perhaps as much as 4 million daltons) under natural conditions.

CA125 参考文献

CA125临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
RG-7882 RG-7882; D-4064A; DMUC-4064A 临床一期 基因泰克 卵巢癌, 胰腺癌 详情
Igovomab 撤市 CIS bio international 卵巢癌
Oregovomab MAb-B43.13; B43.13 临床三期 Paladin Pharma, 美国国立癌症研究所, Quest PharmaTech, University of Nebraska Medical Center 卵巢癌, 胰腺癌 详情
Sofituzumab vedotin RG-7458; DMUC-5754A 临床一期 基因泰克 输卵管癌, 腹膜癌, 卵巢癌, 胰腺癌 详情
JCAR-020 JCAR-020 临床一期 斯隆-凯特琳癌症中心, Juno Therapeutics 卵巢癌 详情

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