LAG-3 靶点蛋白|抗体药物|临床药物信息

LAG-3信息

英文名称：Lymphocyte activation gene 3 protein
中文名称：淋巴细胞活化基因3蛋白
靶点别称：LAG-3，CD223，FDC，LAG3，Protein FDC

上市药物数量：0
临床药物数量：8
最高研发阶段：临床二期

LAG-3产品列表

货号	物种	产品描述
LA3-H5222	Human	Human LAG3 /CD223 Protein
LA3-M52H5	Mouse	Mouse LAG-3 / CD223 Protein
LA3-R52H5	Rat	Rat LAG-3 / CD223 Protein, His Tag
LA3-H5255	Human	Human LAG3 / CD223 Protein, Fc Tag
LA3-C52A0	Cynomolgus	Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag
LA3-H52Aa	Human	Human LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag
LA3-C5252	Cynomolgus	Cynomolgus LAG-3 / CD223 Protein, Fc Tag
LA3-M52Ha	Marmoset	Marmoset LAG-3 / CD223 Protein
LA3-H82F3	Human	Biotinylated Human LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag, Avi Tag
LA3-H522a	Human	Human LAG-3 / CD223 Protein, low endotoxin
LA3-H525c	Human	Human LAG-3 / CD223 Protein, Llama IgG2b Fc Tag, low endotoxin
LA3-H82E5	Human	Biotinylated Human LAG-3 / CD223 Protein, His Tag, Avi Tag
LA3-H82Fb	Human	Biotinylated Human LAG-3 / CD223 Protein, Fc Tag, Avi Tag

LAG-3 分子别名

LAG3,CD223,FDC

LAG-3 分子背景

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.

LAG-3 参考文献

LAG-3临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
LAG-525	LAG-525	临床二期	诺华	实体瘤	详情
IMP-701	IMP-701	临床一期	Immutep, 诺华, CoStim	实体瘤, 血液癌症
IMP-761	IMP-761	临床前	Immutep	自身免疫疾病
FS 118	FS-118	临床一期	F-star, 默克雪兰诺	血液系统恶性肿瘤, 实体瘤	详情
BMS-986016	BMS-986016; Anti-LAG-3; ONO-4482,BMS986016,Anti-LAG-3	临床二期	百时美施贵宝, 小野制药	非小细胞肺癌, 血液系统恶性肿瘤, 实体瘤	详情
Sym-022	Sym-022	临床一期	Symphogen	实体瘤, 淋巴瘤	详情
MGD-013	MGD-013,PD-1 X LAG-3,MGD013; MGD 013	临床一期	MacroGenics	血液系统恶性肿瘤, 实体瘤	详情
GSK-2831781	GSK-2831781; IMP-731, GSK2831781; IMP731	临床一期	Prima BioMed, 葛兰素史克	斑块状银屑病	详情

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LAG-3 重组蛋白