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IL-22信息

英文名称:Interleukin-22
中文名称:白细胞介素-22
靶点别称:ILTIF ,IL22,ZCYTO18,IL-10-related T-cell-derived-inducible factor,Cytokine Zcyto18,IL-22,Interleukin-22,IL-TIF
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

IL-22产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
IL2-H524a
Human
Human IL-22 Protein, His Tag
 
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IL-22 分子别名

IL-22,IL-TIF,ZCYTO18

IL-22 分子背景

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

IL-22 参考文献

IL-22临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Fezakinumab ILV-094; PF-5212367 临床二期 辉瑞 类风湿性关节炎 详情
ILV-095 ILV-095; PF-05212368; PF-5212368; WAY-264095,ILV095; PF05212368; PF5212368; WAY264095,ILV 095; PF 05212368; PF 5212368; WAY 264095 临床一期 惠氏, 辉瑞 银屑病 详情
ARGX-112 ARGX-112; LEO-138559; LP-0145 临床一期 argenx, 利奥制药 特应性皮炎

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