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DLL4信息

英文名称:Delta-like protein 4
中文名称:δ样蛋白-4
靶点别称:Delta-like protein 4,DLL4,Delta4,Drosophila Delta homolog 4
上市药物数量:0
临床药物数量:7
最高研发阶段:临床二期

DLL4产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
DL4-H5227
Human
Human DLL4 Protein, His Tag
DL4-H5259
Human
Human DLL4 /Delta4 Protein, With C-Fc Tag
 
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DLL4 分子别名

DLL4,Delta4

DLL4 分子背景

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.

DLL4 参考文献

DLL4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anti-cancer stem cell monoclonal antibodies (OncoMed) GITRL-336B22; GITRL-336B3; I/O#2; IO#2; IO#3 临床前 OncoMed Pharmaceuticals 癌症
MEDI-0639 21H3RK; MEDI-0639; Anti-DLL-4-MAb, MEDI0639 临床一期 MedImmune 小细胞肺癌 详情
Demcizumab OMP-21M18; OMP-18M21 临床二期 OncoMed Pharmaceuticals, 葛兰素史克, 新基 非小细胞肺癌, 实体瘤, 结肠直肠癌, 卵巢癌, 胰腺癌 详情
TR-009 ABL-001-ABL Bio; ABL001-ABL Bio; NOV-1501 临床一期 ABL Bio, National OncoVenture, TRIGR Therapeutics 实体瘤
Dilpacimab ABT-165; DVD-Ig ABT-165 临床二期 艾伯维 结肠直肠癌 详情
Navicixizumab OMP-305B83 临床一期 OncoMed Pharmaceuticals, 新基 输卵管癌, 实体瘤, 腹膜癌, 卵巢癌 详情
Enoticumab REGN-421; SAR-153192 临床一期 再生元制药, 赛诺菲 实体瘤 详情

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