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CD27信息

英文名称:CD27 antigen
中文名称:CD27抗原
靶点别称:CD27 antigen,Tumor necrosis factor receptor superfamily member 7,CD27L receptor,CD27,CD27 Molecule,T-Cell Activation Antigen CD27,TNFRSF7,T14,T Cell Activation Antigen S152,S152. LPFS2,S152,Tp55,Tumor Necrosis Factor Receptor Superfamily, Member 7
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

CD27 分子别名

CD27,TNFRSF7,S152,T14,Tp55

CD27 分子背景

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 参考文献

CD27临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 临床一期 Aduro Biotech 肿瘤
LOR-S03 CDX-527; LOR-A04; LOR-S01; LOR-S03 临床一期 Celldex 肝癌, 卵巢癌, 头颈癌, 实体瘤, 肾细胞癌, 食道癌, 胃癌, 高微卫星不稳定性癌症, 膀胱癌, 胆管上皮癌, 乳腺癌, 腹膜癌, 结直肠癌, 输卵管癌, 非小细胞肺癌 详情
Varlilumab CDX-1127 临床二期 Celldex 泌尿系疾病, 慢性淋巴细胞白血病, 黑色素瘤, 非小细胞肺癌, 泌尿生殖道肿瘤, 淋巴瘤, 胶质瘤, 非霍奇金淋巴瘤, 泌尿系肿瘤, 套细胞淋巴瘤, 前列腺癌, 卵巢癌, 膀胱癌, 三阴性乳腺肿瘤, 肾脏疾病, 胶质母细胞瘤, 头颈部鳞状细胞癌, 肾细胞癌, 肾肿瘤, 头颈癌, B-细胞淋巴瘤 详情
MK-5890 MK-5890 临床二期 Merck & Co Inc 实体瘤, 三阴性乳腺肿瘤, 非小细胞肺癌 详情

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