CD27 靶点蛋白|抗体药物|临床药物信息

CD27信息

英文名称：CD27 antigen
中文名称：CD27抗原
靶点别称：CD27 antigen，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，CD27 Molecule，T-Cell Activation Antigen CD27，TNFRSF7，T14，T Cell Activation Antigen S152，S152. LPFS2，S152，Tp55，Tumor Necrosis Factor Receptor Superfamily， Member 7

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

CD27产品列表

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产品库

在线 (6)

物种

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属性

Protein (6)

标记

货号	物种	产品描述
CD7-H5254	Human	Human CD27 / TNFRSF7 Protein, Fc Tag (HPLC verified)
TN7-H82F6	Human	Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag
CD7-C5259	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257	Human	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M5252	Mouse	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H522b	Human	Human CD27 / TNFRSF7 Protein, His Tag (MALS Verified)

CD27 分子别名

CD27,TNFRSF7,S152,T14,Tp55

CD27 分子背景

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 参考文献

CD27临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	临床一期	Aduro Biotech	肿瘤
LOR-S03	CDX-527; LOR-A04; LOR-S01; LOR-S03	临床一期	Celldex	肝癌, 卵巢癌, 头颈癌, 实体瘤, 肾细胞癌, 食道癌, 胃癌, 高微卫星不稳定性癌症, 膀胱癌, 胆管上皮癌, 乳腺癌, 腹膜癌, 结直肠癌, 输卵管癌, 非小细胞肺癌	详情
Varlilumab	CDX-1127	临床二期	Celldex	泌尿系疾病, 慢性淋巴细胞白血病, 黑色素瘤, 非小细胞肺癌, 泌尿生殖道肿瘤, 淋巴瘤, 胶质瘤, 非霍奇金淋巴瘤, 泌尿系肿瘤, 套细胞淋巴瘤, 前列腺癌, 卵巢癌, 膀胱癌, 三阴性乳腺肿瘤, 肾脏疾病, 胶质母细胞瘤, 头颈部鳞状细胞癌, 肾细胞癌, 肾肿瘤, 头颈癌, B-细胞淋巴瘤	详情
MK-5890	MK-5890	临床二期	Merck & Co Inc	实体瘤, 三阴性乳腺肿瘤, 非小细胞肺癌	详情

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CD27 重组蛋白