CD27 靶点蛋白|抗体药物|临床药物信息

CD27信息

英文名称：CD27 antigen
中文名称：CD27抗原
靶点别称：T-cell activation antigen CD27，T14，Tumor necrosis factor receptor superfamily member 7，CD27L receptor，CD27，TNFRSF7

上市药物数量：0
临床药物数量：4
最高研发阶段：临床二期

CD27产品列表

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在线 (6)

物种

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属性

Protein (6)

标记

货号	物种	产品描述
CD7-H5254	Human	Human CD27 /TNFRSF7 Protein, With C-Fc Tag
TN7-H82F6	Human	Biotinylated Human CD27 / TNFRSF7 Protein, Fc,Avitag
CD7-C5259	Cynomolgus / Rhesus macaque	Cynomolgus / Rhesus macaque CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H5257	Human	Human CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-M5252	Mouse	Mouse CD27 / TNFRSF7 Protein, Mouse IgG2a Fc Tag, low endotoxin
CD7-H522b	Human	Human CD27 / TNFRSF7 Protein, His Tag

CD27 分子别名

CD27,TNFRSF7,S152,T14,Tp55

CD27 分子背景

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 参考文献

CD27临床药物信息

英文名称	研发代码	研发阶段	公司	适应症	临床试验
MK-5890	MK-5890	临床二期	默沙东	非小细胞肺癌	详情
LOR-S03	CDX-527; LOR-A04; LOR-S01; LOR-S03	临床一期	Celldex	癌症	详情
Anti-CD27 monoclonal antibody (Aduro Biotech)	BION-1402	临床一期	Aduro BioTech, 默沙东	实体瘤
Varlilumab	CDX-1127	临床二期	Celldex, Cascadian Therapeutics, 弗吉尼亚大学	实体瘤, 非霍奇金淋巴瘤, 成胶质细胞瘤, 黑色素瘤	详情

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CD27 重组蛋白