搜索
 > 【CD27】重组蛋白信息

CD27信息

英文名称:CD27 antigen
中文名称:CD27抗原
靶点别称:T-cell activation antigen CD27,T14,Tumor necrosis factor receptor superfamily member 7,CD27L receptor,CD27,TNFRSF7
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

CD27 分子别名

CD27,TNFRSF7,S152,T14,Tp55

CD27 分子背景

CD Antigen CD27 is also known as Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), which belongs to TNF-receptor superfamily. CD27 / TNFRSF7 is found in most T-lymphocytes. CD27 / TNFRSF7 is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.

CD27 参考文献

CD27临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
LOR-S03 CDX-527; LOR-A04; LOR-S01; LOR-S03 临床前 Celldex 癌症
Anti-CD27 monoclonal antibody (Aduro Biotech) BION-1402 临床一期 Aduro BioTech, 默沙东 实体瘤
Varlilumab CDX-1127 临床二期 Celldex, Cascadian Therapeutics, 弗吉尼亚大学 前列腺癌, 血液系统恶性肿瘤, 乳腺癌, 实体瘤, 卵巢癌, 肾癌, 黑色素瘤 详情

消息提示

请输入您的联系方式,再点击提交!

确定