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Human CD79B Protein, Fc Tag

分子别名(Synonym)

CD79b,B29,IGB,Ig-beta

表达区间及表达系统(Source)

Human CD79B, Fc Tag (CDB-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 29 - Asp 159 (Accession # NP_000617).

Predicted N-terminus: Ala 29

蛋白结构(Molecular Characterization)

Online(Ala 29 - Asp 159) NP_000617

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 41.8 kDa. The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human CD79B, Fc Tag (Cat. No. CDB-H5259) SDS-PAGE gel

Human CD79B, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

>获取HPLC数据

文献引用(Citations)

背景(Background)

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

 

前沿进展

 
货号/价格

CDB-H5259-100ug / ¥2900

CDB-H5259-1mg / ¥18000

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CD79B靶点信息
英文全称:B-cell antigen receptor complex-associated protein beta chain
中文全称:B细胞抗原受体复合物相关蛋白β链
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:2详情
最高研发阶段:批准上市
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