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CD79B信息

英文名称:B-cell antigen receptor complex-associated protein beta chain
中文名称:B细胞抗原受体复合物相关蛋白β链
靶点别称:Ig-beta,CD79b,B29,IGB,Immunoglobulin-associated B29 protein,B-cell-specific glycoprotein B29,CD79B
上市药物数量:0
临床药物数量:2
最高研发阶段:BLA 申请

CD79B产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CDB-H5259
Human
Recombinant Human CD79B Protein

CD79B 分子别名

CD79b,B29,IGB,Ig-beta

CD79B 分子背景

B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

CD79B 参考文献

CD79B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PRV-3279 PRV-3279; MGD-010; CD32BxCD79B 临床一期 MacroGenics, Provention Bio 自身免疫疾病 详情
Polatuzumab vedotin FCU-2711; RG-7596; RO-5541077; RO-5541077-000, FCU2711; RG7596; RO5541077; RO5541077-000; RO5541077000 BLA 申请 基因泰克, Seattle Genetics, 中外制药 慢性淋巴细胞白血病, 弥漫大B细胞淋巴瘤, 滤泡性淋巴瘤, 非霍奇金淋巴瘤 详情

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