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MIF信息

英文名称:Macrophage migration inhibitory factor
中文名称:巨噬细胞移动抑制因子
靶点别称:L-dopachrome tautomerase,Macrophage migration inhibitory factor,Glycosylation-inhibiting factor,L-dopachrome isomerase,GLIF ,GIF,MMIF,MIF,Phenylpyruvate tautomerase
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

MIF产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MIF-H82E7
Human
Biotinylated Human MIF Protein, His,Avitag
 
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MIF Molecule Synonym Name

MIF,GLIF,MMIF,GIF

MIF 分子背景

Macrophage migration inhibitory factor(MIF) is also known as Glycosylation-inhibiting factor(GIF), L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase. Interacts with CXCR2 extracellular domain, CD74 extracellular domain, COPS5 and BNIPL. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

MIF 参考文献

MIF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CPSI-2705 CPS1-2705 临床前 Cytokine PharmaSciences 感染类疾病, 免疫性疾病
Imalumab BAX-069; BAX-69 临床二期 Cytokine PharmaSciences, Baxalta 红斑狼疮性肾炎, 实体瘤, 结肠直肠癌, 恶性腹腔积液 详情
R-ISO-15 临床前 辉凌制药 脓毒症
CBX-21404 CBX-21404,CBX21404 临床前 Ciblex 自身免疫疾病, 前列腺癌, 乳腺癌, 炎症

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