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Siglec-15信息

英文名称:Sialic acid-binding Ig-like lectin 15
中文名称:唾液酸结合免疫球蛋白样凝集素-15
靶点别称:SIGLEC15,CD33L3,CD33 antigen-like 3,Siglec-15
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Siglec-15产品列表

 
评论(6)
SG5-C52H6|Cynomolgus Siglec-15 / CD33L3 Protein, His Tag
  1. 182XXXXXXX2
  2. 0人赞
  3. 三个种属的Siglec15都使用过分别用来测定同一个抗体的亲和力,猴子的亲和力与人的相当,大约为7E-10
  4. >
  5. 2020-01-10
SG5-M52H7|Mouse Siglec-15 / CD33L3 Protein, His Tag
  1. 182XXXXXXX2
  2. 2人赞
  3. Mouse SIglec15与抗癌新药做亲和力测定,有一定的解离趋势,但是亲和力还有2E-9.
  4. >
  5. 2020-01-10
SG5-H52H3|Human Siglec-15 / CD33L3 Protein, His Tag
  1. 182XXXXXXX2
  2. 3人赞
  3. 到货速度很快的产品,使用一款临床期的抗体与Human Siglec15做BLI实验,结果显而易见,具有很高的亲和力,解离速度很慢。
  4. >
  5. 2020-01-10
 

Siglec-15 Molecule Synonym Name

CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

Siglec-15 分子背景

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Siglec-15 参考文献

Siglec-15临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
DS-1501 DS-1501 临床一期 第一三共 骨质疏松症
NC-318 5G-12; NC-318 临床二期 耶鲁大学医学院, NextCure 实体瘤 详情

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