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GPA33信息

英文名称:Cell surface A33 antigen
中文名称:细胞表面A33抗原
靶点别称:Glycoprotein A33,GPA33
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

GPA33产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
GP3-H8224
Human
Biotinylated Human GPA33 Protein, His Tag, ultra sensitivity (primary amine labeling)
GP3-H5224
Human
Human Glycoprotein A33 GPA33 Protein
GP3-M5225
Mouse
Mouse GPA33 / A33 Protein, His Tag

GPA33 分子别名

GPA33,A33

GPA33 分子背景

Glycoprotein A33 (GPA33) is also known as Cell surface A33 antigen, is a single-pass type I membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily, which contains. GPA33 may play a role in cell-cell recognition and signaling.

GPA33 参考文献

GPA33临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Anticancer monoclonal antibody A33 (Ludwig Institute for Cancer Research) 124I-huA33; 131I-huA33; 131I-huAb A33 临床一期 路德维格癌症研究所 结肠直肠癌 详情
MGD-007 MGD-007; gpA33-xCD3 临床一期 MacroGenics, 施维雅 结肠直肠癌 详情
A33-radionuclides CDP-833; hA33-90Y 临床一期 Celltech 结肠直肠癌 详情
KRN-330 KRN-330 临床二期 协和发酵麒麟 结肠直肠癌 详情

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